OLR1

Across TCGA patient cohorts, OLR1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OLR1-associated genes across cancer lineages are p38-MAPK, PCNA, and Ku80. Each is linked with OLR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OLR1-to-partner and partner-to-OLR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK grouped by OLR1-low versus OLR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLR1→partner) and Y-score (partner→OLR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK →	-0.135	-1.807	.047	.027	3	2
UCEC	PCNA →	+0.189	+1.807	.034	.027	3	2
UCEC	Ku80 →	+0.239	+1.820	.014	.016	3	1
UCEC	Notch1 →	+0.122	+2.469	.035	.010	3	1
UCEC	p27_pT198 →	+0.130	+3.459	.003	.005	3	1
UCEC	P-Cadherin →	-0.136	-2.986	.022	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

p38-MAPK by OLR1 expression — UCEC

Explore this box plot interactively →