Across TCGA pan-cancer cohorts, OLFML2A mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of OLFML2A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where OLFML2A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types OLFML2A is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

CCRCC, LUAD, and HNSC are the cancer types where OLFML2A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OLFML2A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	IV	+1.100	<.001	12	view →
LUAD	Female	II,III,IV	−1.108	<.001	9	view →
HNSC	All	All	+0.277	.013	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: OLFML2A RNA expression & survival · all OLFML2A data types