OLFM4

Across TCGA patient cohorts, OLFM4 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OLFM4-associated genes across cancer lineages are eEF2, 4E-BP1, and FoxM1. Each is linked with OLFM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both OLFM4-to-partner and partner-to-OLFM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by OLFM4-low versus OLFM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFM4→partner) and Y-score (partner→OLFM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.341	+2.321	.008	.033	3	3
UCEC	4E-BP1 →	+0.335	+2.730	<.001	.003	2	3
UCEC	FoxM1 →	+0.199	+2.321	.033	.001	3	2
UCEC	MEK1 →	+0.422	+4.000	.001	<.001	3	2
UCEC	PCNA →	+0.199	+2.115	.010	.017	3	2
UCEC	Annexin-1 →	+0.463	+2.479	.014	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eEF2 by OLFM4 expression — UCEC

Explore this box plot interactively →