OLFM4

Across TCGA cell cohorts, OLFM4 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OLFM4-associated genes across cancer lineages are TBX18, NDUFB10, and PACRGL. Each is linked with OLFM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OLFM4-to-partner and partner-to-OLFM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBX18 grouped by OLFM4-low versus OLFM4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFM4→partner) and Y-score (partner→OLFM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBX18 →	+1.402	+3.215	<.001	.009	3	1
LARGE_INTESTINE	NDUFB10 →	+0.616	+3.067	<.001	.009	3	1
LARGE_INTESTINE	PACRGL →	+0.623	+3.067	.001	.009	3	1
LARGE_INTESTINE	ADCY1 →	+1.388	+3.082	<.001	.007	3	1
LARGE_INTESTINE	REG1B →	+2.644	+3.196	<.001	<.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

TBX18 by OLFM4 expression — LARGE_INTESTINE

Explore this box plot interactively →