OLFM4

Across TCGA cell cohorts, OLFM4 mutation is significantly associated with the mutation status of many other genes, with 3,364 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OLFM4-associated genes across cancer lineages are JPH2, SV2C, and NFATC2. Each is linked with OLFM4 in more than 3 cancer types. Because this analysis shows association rather than direction, both OLFM4-to-partner and partner-to-OLFM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JPH2 grouped by OLFM4-low versus OLFM4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OLFM4→partner) and Y-score (partner→OLFM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	JPH2 →	+2.392	+3.050	.001	.001	1	4
LUNG_NSCLC_LUAD	SV2C →	+4.772	+5.339	.004	.004	1	3
BLOOD_Leukemia	NFATC2 →	+2.779	+4.326	.006	.006	1	3
BLOOD_Leukemia	COL20A1 →	+3.479	+4.932	.002	.002	1	3
BLOOD_Leukemia	PCDH11X →	+4.157	+5.430	<.001	<.001	1	3
BLOOD_Leukemia	ADCY2 →	+3.672	+5.083	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,364 associations by consensus.

JPH2 by OLFM4 expression — LARGE_INTESTINE

Explore this box plot interactively →