OIT3

Across TCGA patient cohorts, OIT3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OIT3-associated genes across cancer lineages are Cyclin-B1, PCNA, and FoxM1. Each is linked with OIT3 in more than 2 cancer types. Because this analysis shows association rather than direction, both OIT3-to-partner and partner-to-OIT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by OIT3-low versus OIT3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OIT3→partner) and Y-score (partner→OIT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Cyclin-B1 →	+0.499	+3.169	.006	.017	3	3
UCEC	PCNA →	+0.295	+3.459	<.001	.005	3	3
SKCM	FoxM1 →	+0.326	+3.459	<.001	.005	3	2
SKCM	PARP_cleaved →	+0.149	+2.700	.032	.006	3	2
UCEC	eIF4E →	+0.200	+2.415	.018	.003	3	2
UCEC	MEK1 →	+0.386	+3.321	.008	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Cyclin-B1 by OIT3 expression — SKCM

Explore this box plot interactively →