OGN

Across TCGA pan-cancer cohorts, OGN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OGN data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher OGN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated OGN expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where OGN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.624	0.418	.011	25	view →
HNSC	OS	Median	All	1.000	0.484	.038	12	view →
CCRCC	DFS	Median	II,III,IV	0.199	0.839	.011	11	view →
LSCC	DFS	Median	II,III,IV	0.828	1.000	.002	10	view →
LUAD	DFS	Quartile	III,IV	0.275	0.944	.006	9	view →
GBM	OS	Median	All	0.277	0.503	.009	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OGN–PDAC (OS)

Open the PDAC breakdown →