OGN

Across TCGA patient cohorts, OGN mutation is significantly associated with the RNA expression of many other genes, with 2,759 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGN-associated genes across cancer lineages are H2AC14, MIR4752, and OR4B2P. Each is linked with OGN in more than 1 cancer types. Because this analysis shows association rather than direction, both OGN-to-partner and partner-to-OGN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AC14 grouped by OGN-low versus OGN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGN→partner) and Y-score (partner→OGN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H2AC14 →	+0.793	+2.338	<.001	.003	3	2
LUAD	MIR4752 →	+0.457	+6.584	<.001	.001	3	2
SKCM	OR4B2P →	+0.055	+5.328	<.001	.003	3	2
READ	RN7SL578P →	+0.172	+5.039	<.001	.008	3	2
LIHC	RNU1-62P →	+0.159	+5.317	<.001	.002	3	2
LIHC	SNORD105B →	+0.433	+4.289	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,759 associations by consensus.

H2AC14 by OGN expression — UCEC

Explore this box plot interactively →