OGFR

Across TCGA pan-cancer cohorts, OGFR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OGFR data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher OGFR mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated OGFR expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where OGFR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.592	1.000	.003	35	view →
PDAC	OS	Tertile	All	0.250	0.479	.007	21	view →
CCRCC	DFS	Quartile	III,IV	0.300	0.895	.004	8	view →
LUAD	OS	Quartile	All	1.000	0.865	.025	7	view →
HNSC	DFS	Median	IV	1.000	0.924	.037	2	view →
UCEC	DFS	Quartile	All	0.804	0.947	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OGFR–LSCC (OS)

Open the LSCC breakdown →