OGFOD2

Across TCGA patient cohorts, OGFOD2 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGFOD2-associated genes across cancer lineages are A-Raf_pS299, MEK1, and Shc_pY317. Each is linked with OGFOD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OGFOD2-to-partner and partner-to-OGFOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by OGFOD2-low versus OGFOD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGFOD2→partner) and Y-score (partner→OGFOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.155	-2.115	<.001	.017	3	2
UCEC	MEK1 →	+0.439	+2.906	.001	.001	3	2
UCEC	Shc_pY317 →	-0.143	-2.087	.013	.005	3	2
UCEC	Cyclin-B1 →	+0.528	+2.321	.014	.033	3	2
UCEC	14-3-3_beta →	-0.088	-2.295	.022	.033	3	1
UCEC	EGFR_pY1068 →	-0.203	-1.678	.034	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

A-Raf_pS299 by OGFOD2 expression — UCEC

Explore this box plot interactively →