OGFOD1

Across TCGA patient cohorts, OGFOD1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGFOD1-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and MEK1. Each is linked with OGFOD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OGFOD1-to-partner and partner-to-OGFOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by OGFOD1-low versus OGFOD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGFOD1→partner) and Y-score (partner→OGFOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.360	-3.459	.004	.005	3	1
UCEC	INPP4B →	-0.361	-2.999	.026	.035	3	1
UCEC	MEK1 →	+0.370	+3.000	.044	.036	3	1
UCEC	Mre11 →	-0.104	-3.459	.016	.005	3	1
UCEC	MSH6 →	-0.503	-2.990	.002	.036	3	1
UCEC	mTOR_pS2448 →	-0.176	-2.986	.018	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

EGFR_pY1068 by OGFOD1 expression — UCEC

Explore this box plot interactively →