Across TCGA patient cohorts, OGDHL mutation is significantly associated with the RNA expression of many other genes, with 5,807 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGDHL-associated genes across cancer lineages are RAD51, DCST1-AS1, and FAM107A. Each is linked with OGDHL in more than 4 cancer types. Because this analysis shows association rather than direction, both OGDHL-to-partner and partner-to-OGDHL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGDHL→partner) and Y-score (partner→OGDHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAD51 →	+0.759	+2.098	<.001	<.001	3	5
BLCA	DCST1-AS1 →	+0.959	+3.372	<.001	.005	2	5
LUSC	FAM107A →	-0.692	-2.584	.008	.001	2	5
SKCM	IQGAP3 →	+0.463	+2.109	<.001	<.001	3	4
LUAD	POLE2 →	+0.508	+3.471	.005	.002	3	4
COAD	MICU1 →	+0.410	+2.834	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,807 associations by consensus.

Exploration

OGDHL survival (RNA) · tumor vs normal (RNA) · all OGDHL data types