Across TCGA patient cohorts, OGDHL mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGDHL-associated genes across cancer lineages are ASNS, EGFR_pY1068, and Cyclin-E2. Each is linked with OGDHL in more than 4 cancer types. Because this analysis shows association rather than direction, both OGDHL-to-partner and partner-to-OGDHL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGDHL→partner) and Y-score (partner→OGDHL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.529	+2.321	.004	.033	3	5
UCEC	EGFR_pY1068 →	-0.212	-1.777	.003	.001	3	4
LUSC	Cyclin-E2 →	+0.124	+2.179	.039	.035	3	3
UCEC	mTOR_pS2448 →	-0.123	-1.757	.004	.001	3	3
UCEC	PDCD4 →	-0.436	-1.169	.001	.017	3	3
UCEC	Src_pY416 →	-0.139	-0.986	.045	.042	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Exploration

OGDHL survival (RNA) · tumor vs normal (RNA) · all OGDHL data types