OGDH

Across TCGA pan-cancer cohorts, OGDH Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OGDH data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher OGDH Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated OGDH expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, READ, and BRCA are the cancer types where OGDH Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
READ	OS	Median	All	0.166	0.830	<.001	14	view →
BRCA	DFS	Median	III,IV	0.093	0.880	<.001	13	view →
BLCA	DFS	Median	All	0.250	0.608	.004	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	II,III,IV	0.836	0.303	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OGDH–ACC (DFS)

Open the ACC breakdown →