OGDH

Across TCGA pan-cancer cohorts, OGDH mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OGDH data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher OGDH mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OGDH expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

UCEC, LSCC, and HNSC are the cancer types where OGDH mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Quartile	All	0.755	1.000	.006	20	view →
LSCC	DFS	Median	All	0.906	0.973	.005	10	view →
HNSC	DFS	Tertile	III,IV	0.793	0.512	.021	6	view →
OV	DFS	Quartile	All	0.923	0.612	.017	4	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	3	view →
LUAD	DFS	Quartile	All	0.880	0.978	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OGDH–UCEC (DFS)

Open the UCEC breakdown →