OGDH

Across TCGA patient cohorts, OGDH mutation is significantly associated with the RNA expression of many other genes, with 3,953 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGDH-associated genes across cancer lineages are OIP5, LLPH, and PRF1. Each is linked with OGDH in more than 3 cancer types. Because this analysis shows association rather than direction, both OGDH-to-partner and partner-to-OGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OIP5 grouped by OGDH-low versus OGDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGDH→partner) and Y-score (partner→OGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OIP5 →	+0.667	+1.895	<.001	<.001	3	4
SKCM	LLPH →	+0.413	+3.227	.002	<.001	3	4
UCEC	PRF1 →	+1.168	+2.108	<.001	<.001	3	3
UCEC	KMT5A →	+0.350	+2.021	<.001	.001	3	3
COAD	ARHGAP11A →	+0.611	+2.595	.005	.006	3	3
UCEC	PRC1 →	+0.600	+2.279	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,953 associations by consensus.

OIP5 by OGDH expression — UCEC

Explore this box plot interactively →