OGDH

Across TCGA patient cohorts, OGDH mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGDH-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and PAI-1. Each is linked with OGDH in more than 3 cancer types. Because this analysis shows association rather than direction, both OGDH-to-partner and partner-to-OGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by OGDH-low versus OGDH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGDH→partner) and Y-score (partner→OGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.309	+2.467	<.001	.011	3	4
UCEC	ATM →	-0.412	-1.415	.003	.010	3	3
SKCM	PAI-1 →	+0.608	+2.186	.029	.032	3	2
UCEC	Cyclin-B1 →	+0.546	+2.321	.001	.005	3	2
UCEC	eIF4E →	+0.175	+2.920	.007	<.001	3	2
COAD	ERK2 →	+0.188	+3.000	.025	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by OGDH expression — COAD

Explore this box plot interactively →