OGDH

Across TCGA cell cohorts, OGDH RNA expression is significantly associated with the go_rna of many other GO terms, with 3,829 significant associations in total. CNS shows the largest number of these associations.

The most reproducible OGDH-associated GO terms across cancer lineages are 2-oxoglutarate decarboxylation to succinyl-CoA, Thalamus development, and Aerobic respiration. Each is linked with OGDH in more than 19 cancer types. Because this analysis shows association rather than direction, both OGDH-to-partner and partner-to-OGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 2-oxoglutarate decarboxylation to succinyl-CoA grouped by OGDH-low versus OGDH-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OGDH→partner) and Y-score (partner→OGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	2-oxoglutarate decarboxylation to succinyl-CoA →	+0.160	+1.641	<.001	<.001	3	20
BLOOD_Myeloma	Thalamus development →	+0.177	+1.096	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Aerobic respiration →	+0.099	+1.040	<.001	<.001	3	13
OESOPHAGUS	Vesicle-mediated transport to the plasma membrane →	+0.097	+1.333	<.001	<.001	3	13
OESOPHAGUS	Endosomal transport →	+0.073	+1.192	.001	.003	3	12
OESOPHAGUS	Endocytic recycling →	+0.089	+1.333	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,829 associations by consensus.

2-oxoglutarate decarboxylation to succinyl-CoA by OGDH expression — BLOOD_Myeloma

Explore this box plot interactively →