OGDH

Across TCGA cell cohorts, OGDH mutation is significantly associated with the RNA expression of many other genes, with 374 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OGDH-associated genes across cancer lineages are PRAMEF20, SH3GL2, and TAS1R2. Each is linked with OGDH in more than 1 cancer types. Because this analysis shows association rather than direction, both OGDH-to-partner and partner-to-OGDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF20 grouped by OGDH-low versus OGDH-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGDH→partner) and Y-score (partner→OGDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRAMEF20 →	+0.013	+4.906	<.001	.006	3	2
LARGE_INTESTINE	SH3GL2 →	+1.120	+3.474	.002	.003	3	2
CNS	TAS1R2 →	+0.024	+4.643	<.001	.003	3	2
BLOOD_Leukemia	VWC2L →	+0.008	+3.661	.001	.001	3	2
BLOOD_Leukemia	CENPVL1 →	+0.209	+3.556	.002	.001	3	2
OESOPHAGUS	PROP1 →	+0.030	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 374 associations by consensus.

PRAMEF20 by OGDH expression — OESOPHAGUS

Explore this box plot interactively →