Across TCGA patient cohorts, OGA mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OGA-associated genes across cancer lineages are mTOR_pS2448, Notch1, and eIF4E. Each is linked with OGA in more than 2 cancer types. Because this analysis shows association rather than direction, both OGA-to-partner and partner-to-OGA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGA→partner) and Y-score (partner→OGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.144	-2.401	.002	.002	3	3
UCEC	Notch1 →	+0.191	+2.058	<.001	<.001	3	3
UCEC	eIF4E →	+0.167	+3.472	.013	.002	3	2
UCEC	INPP4B →	-0.269	-2.222	.009	.009	3	2
UCEC	S6_pS240_S244 →	+0.328	+2.502	.011	.001	3	2
UCEC	STAT3_pY705 →	-0.412	-2.058	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

OGA survival (RNA) · tumor vs normal (RNA) · all OGA data types