Across TCGA cell cohorts, OGA mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible OGA-associated genes across cancer lineages are C4orf50, TRIM77, and CT45A6. Each is linked with OGA in more than 1 cancer types. Because this analysis shows association rather than direction, both OGA-to-partner and partner-to-OGA results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OGA→partner) and Y-score (partner→OGA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C4orf50 →	+0.013	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.030	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	CT45A6 →	+0.060	+5.357	<.001	.003	3	1
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

OGA survival (RNA) · tumor vs normal (RNA) · all OGA data types