OFD1

Across TCGA pan-cancer cohorts, OFD1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OFD1 data layer compared with 28 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher OFD1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated OFD1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

LUAD, UCEC, and HNSC are the cancer types where OFD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	III,IV	0.797	0.436	.004	22	view →
UCEC	DFS	Tertile	All	0.984	0.833	.016	8	view →
HNSC	OS	Median	All	1.000	0.449	.033	6	view →
LSCC	DFS	Median	II,III,IV	0.878	0.677	.014	3	view →
CCRCC	OS	Median	III,IV	0.721	0.917	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OFD1–LUAD (OS)

Open the LUAD breakdown →