OFD1

Across TCGA patient cohorts, OFD1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OFD1-associated genes across cancer lineages are PDCD4, ATM, and INPP4B. Each is linked with OFD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both OFD1-to-partner and partner-to-OFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by OFD1-low versus OFD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OFD1→partner) and Y-score (partner→OFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.509	-1.716	<.001	.003	3	4
UCEC	ATM →	-0.513	-2.794	<.001	.002	3	3
UCEC	INPP4B →	-0.300	-1.847	.004	.007	3	2
UCEC	Ku80 →	+0.212	+1.235	.005	.023	3	2
UCEC	mTOR_pS2448 →	-0.099	-1.658	.040	.021	3	2
UCEC	STAT3_pY705 →	-0.343	-1.584	<.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PDCD4 by OFD1 expression — UCEC

Explore this box plot interactively →