ODR4

Across TCGA patient cohorts, ODR4 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ODR4-associated genes across cancer lineages are 14-3-3_beta, JNK2, and Notch1. Each is linked with ODR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ODR4-to-partner and partner-to-ODR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ODR4-low versus ODR4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ODR4→partner) and Y-score (partner→ODR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.129	-2.571	.005	.011	3	1
UCEC	JNK2 →	+0.217	+2.584	.018	.011	3	1
UCEC	Notch1 →	+0.150	+2.584	.022	.011	3	1
UCEC	TIGAR →	+0.142	+2.611	.045	.006	3	1
UCEC	Tuberin →	+0.340	+2.331	.006	.019	3	1
UCEC	VHL →	-0.854	-3.169	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

14-3-3_beta by ODR4 expression — UCEC

Explore this box plot interactively →