ODF3L1

Across TCGA pan-cancer cohorts, ODF3L1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ODF3L1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ODF3L1 RNA is repressed in tumor relative to normal tissue. In most cancer types ODF3L1 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, HNSC, and LUAD are the cancer types where ODF3L1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ODF3L1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−2.347	<.001	12	view →
HNSC	Male	All	+0.995	<.001	10	view →
LUAD	Female	III,IV	−1.875	<.001	9	view →
LUSC	Male	II,III,IV	−1.656	<.001	8	view →
THCA	Female	All	−1.647	<.001	8	view →
UCEC	All	All	−0.945	<.001	8	view →
KICH	All	II,III,IV	−0.858	<.001	7	view →
BRCA	All	III,IV	−1.463	<.001	6	view →
KIRC	Male	All	+0.353	<.001	5	view →
KIRP	All	All	+0.551	<.001	4	view →
LIHC	Male	All	−0.657	<.001	3	view →
CHOL	All	II,III,IV	−0.674	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ODF3L1–BLCA

Open the BLCA breakdown →