ODF2

Across TCGA cell cohorts, ODF2 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ODF2-associated genes across cancer lineages are PYDC2, RS1, and BHLHE23. Each is linked with ODF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ODF2-to-partner and partner-to-ODF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYDC2 grouped by ODF2-low versus ODF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ODF2→partner) and Y-score (partner→ODF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PYDC2 →	+0.108	+4.415	<.001	.007	3	2
BLOOD_Leukemia	RS1 →	+0.095	+3.301	<.001	.001	3	2
BLOOD_Leukemia	BHLHE23 →	+1.525	+2.632	<.001	.009	3	2
BLOOD_Lymphoma	CABP5 →	+0.011	+4.452	<.001	.001	3	2
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
LARGE_INTESTINE	OR4F4 →	+0.025	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PYDC2 by ODF2 expression — LARGE_INTESTINE

Explore this box plot interactively →