ODC1

Across TCGA patient cohorts, ODC1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ODC1-associated genes across cancer lineages are Cyclin-B1, FoxM1, and INPP4B. Each is linked with ODC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ODC1-to-partner and partner-to-ODC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by ODC1-low versus ODC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ODC1→partner) and Y-score (partner→ODC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.705	+2.584	.007	.011	3	2
UCEC	FoxM1 →	+0.325	+2.179	.007	.034	3	1
UCEC	INPP4B →	-0.304	-2.999	.044	.035	3	1
UCEC	Ku80 →	+0.257	+3.013	.019	.018	3	1
UCEC	Notch1 →	+0.206	+3.179	.001	.010	3	1
UCEC	p62 Lck ligand →	+0.329	+3.009	.030	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Cyclin-B1 by ODC1 expression — UCEC

Explore this box plot interactively →