ODAPH

Across TCGA pan-cancer cohorts, ODAPH RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ODAPH data layer compared with 2 for mutation status.

The strongest signal is observed in thyroid carcinoma (THCA), where higher ODAPH RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ODAPH expression acts as an unfavorable survival marker, although some lineages such as SKCM and ESCA show a favorable association.

THCA, KIRC, and SKCM are the cancer types where ODAPH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	OS	Median	All	0.891	0.987	<.001	112	view →
KIRC	OS	Median	All	0.503	0.721	<.001	106	view →
SKCM	OS	Tertile	III,IV	0.541	0.268	<.001	51	view →
KICH	DFS	Tertile	All	0.625	1.000	.003	39	view →
MESO	DFS	Median	II,III,IV	0.295	0.444	.008	29	view →
BLCA	OS	Quartile	All	0.497	0.650	.002	27	view →
LGG	DFS	Median	All	0.781	0.878	<.001	26	view →
ESCA	DFS	Tertile	III,IV	0.630	0.251	.001	18	view →
HNSC	OS	Quartile	All	0.718	0.824	.019	18	view →
CESC	DFS	Quartile	III,IV	0.501	0.842	.008	12	view →
DLBC	DFS	Median	III,IV	1.000	0.525	.013	11	view →
THYM	DFS	Median	II,III,IV	0.745	0.956	.009	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ODAPH–THCA (OS)

Open the THCA breakdown →