OCRL

Across TCGA pan-cancer cohorts, OCRL Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated OCRL data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OCRL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated OCRL expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

HNSC, UCEC, and THYM are the cancer types where OCRL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.081	0.756	<.001	36	view →
UCEC	DFS	Median	All	0.957	0.605	<.001	36	view →
THYM	DFS	Median	All	0.092	0.872	<.001	6	view →
READ	DFS	Median	III,IV	0.182	0.745	.007	6	view →
STAD	OS	Median	IV	0.074	0.540	.024	6	view →
BLCA	DFS	Median	All	1.000	0.329	.033	6	view →
COAD	OS	Median	II,III,IV	0.267	0.792	.017	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

OCRL–HNSC (OS)

Open the HNSC breakdown →