OCRL

Across TCGA pan-cancer cohorts, OCRL mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OCRL data layer compared with 28 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OCRL mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OCRL expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, GBM, and CCRCC are the cancer types where OCRL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.264	0.886	.002	20	view →
GBM	DFS	Quartile	All	0.901	0.600	.001	15	view →
CCRCC	DFS	Median	All	0.541	0.922	.004	13	view →
LUAD	DFS	Tertile	II,III,IV	0.726	1.000	.018	12	view →
LSCC	OS	Tertile	All	0.785	0.916	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OCRL–HNSC (DFS)

Open the HNSC breakdown →