OCRL

Across TCGA patient cohorts, OCRL mutation is significantly associated with the RNA expression of many other genes, with 5,546 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OCRL-associated genes across cancer lineages are OR9A3P, KIF9-AS1, and P2RY11. Each is linked with OCRL in more than 2 cancer types. Because this analysis shows association rather than direction, both OCRL-to-partner and partner-to-OCRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9A3P grouped by OCRL-low versus OCRL-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OCRL→partner) and Y-score (partner→OCRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	OR9A3P →	+0.660	+3.558	<.001	.007	3	3
UCEC	KIF9-AS1 →	+0.319	+1.652	<.001	<.001	3	3
UCEC	P2RY11 →	+0.361	+1.152	<.001	.003	3	3
UCEC	RBBP8 →	+0.575	+2.711	<.001	<.001	3	3
UCEC	ACYP1 →	+0.326	+1.291	<.001	<.001	3	3
UCEC	ATP1B2 →	-0.535	-2.525	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,546 associations by consensus.

OR9A3P by OCRL expression — BRCA

Explore this box plot interactively →