OCRL

Across TCGA cell cohorts, OCRL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,363 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible OCRL-associated GO terms across cancer lineages are Post-Golgi vesicle-mediated transport, Regulation of organelle assembly, and Regulation of post-transcriptional gene silencing. Each is linked with OCRL in more than 12 cancer types. Because this analysis shows association rather than direction, both OCRL-to-partner and partner-to-OCRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-Golgi vesicle-mediated transport grouped by OCRL-low versus OCRL-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OCRL→partner) and Y-score (partner→OCRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Post-Golgi vesicle-mediated transport →	+0.061	+0.733	.001	.005	3	13
LARGE_INTESTINE	Regulation of organelle assembly →	+0.031	+0.530	.001	.001	3	13
LUNG_SCLC	Regulation of post-transcriptional gene silencing →	+0.119	+0.751	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Negative regulation of macroautophagy →	+0.067	+0.908	<.001	<.001	3	12
CNS	Cytosolic ciliogenesis →	+0.085	+0.475	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Stress granule assembly →	+0.108	+0.847	.007	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,363 associations by consensus.

Post-Golgi vesicle-mediated transport by OCRL expression — LUNG_SCLC

Explore this box plot interactively →