Across TCGA patient cohorts, OCLN mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OCLN-associated genes across cancer lineages are Notch1, JNK2, and Ku80. Each is linked with OCLN in more than 1 cancer types. Because this analysis shows association rather than direction, both OCLN-to-partner and partner-to-OCLN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OCLN→partner) and Y-score (partner→OCLN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.234	+3.169	.002	.020	3	2
UCEC	JNK2 →	+0.360	+2.817	<.001	.036	3	1
UCEC	Ku80 →	+0.326	+3.183	.012	.010	3	1
UCEC	p62 Lck ligand →	+0.466	+2.817	.009	.036	3	1
UCEC	Paxillin →	+0.380	+3.013	.007	.018	3	1
UCEC	4E-BP1 →	+0.426	+2.837	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

OCLN survival (RNA) · tumor vs normal (RNA) · all OCLN data types