OCA2

Across TCGA pan-cancer cohorts, OCA2 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated OCA2 data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher OCA2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated OCA2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, THYM, and BLCA are the cancer types where OCA2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	IV	0.342	0.893	<.001	16	view →
THYM	DFS	Median	All	0.123	0.871	<.001	12	view →
BLCA	OS	Median	III,IV	0.331	0.588	.028	12	view →
LUSC	DFS	Median	III,IV	0.079	0.751	.024	6	view →
UCEC	OS	Median	II,III,IV	0.892	0.457	.032	6	view →
ESCA	OS	Median	All	0.284	0.683	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

OCA2–LUAD (DFS)

Open the LUAD breakdown →