OCA2

Across TCGA patient cohorts, OCA2 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OCA2-associated genes across cancer lineages are FoxM1, 4E-BP1, and GAPDH. Each is linked with OCA2 in more than 4 cancer types. Because this analysis shows association rather than direction, both OCA2-to-partner and partner-to-OCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by OCA2-low versus OCA2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OCA2→partner) and Y-score (partner→OCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FoxM1 →	+0.256	+2.584	.013	.010	3	5
LUSC	4E-BP1 →	+0.283	+1.494	.045	.035	3	4
COAD	GAPDH →	+0.551	+3.178	.002	<.001	3	4
STAD	PCNA →	+0.276	+3.584	.010	.002	3	4
COAD	Caspase-7-cleavedD198 →	+0.954	+1.593	<.001	.022	3	4
COAD	Cyclin-E2 →	+0.192	+2.832	.019	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

FoxM1 by OCA2 expression — LUSC

Explore this box plot interactively →