OCA2

Across TCGA cell cohorts, OCA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,504 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible OCA2-associated GO terms across cancer lineages are Melanin biosynthetic process from tyrosine, Amino acid activation, and tRNA aminoacylation. Each is linked with OCA2 in more than 9 cancer types. Because this analysis shows association rather than direction, both OCA2-to-partner and partner-to-OCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Melanin biosynthetic process from tyrosine grouped by OCA2-low versus OCA2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OCA2→partner) and Y-score (partner→OCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Melanin biosynthetic process from tyrosine →	+1.108	+2.727	<.001	<.001	3	10
SKIN	Amino acid activation →	+0.045	+1.717	.001	.004	3	9
SKIN	tRNA aminoacylation →	+0.045	+1.717	.001	.004	3	9
STOMACH	Granzyme-mediated apoptotic signaling pathway →	+0.134	+1.077	.001	.009	3	7
STOMACH	Nucleic acid catabolic process →	+0.067	+0.948	<.001	.006	2	8
LIVER	Positive regulation of monoatomic ion transmembrane transport →	-0.158	-1.568	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,504 associations by consensus.

Melanin biosynthetic process from tyrosine by OCA2 expression — SKIN

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