OC90

Across TCGA patient cohorts, OC90 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible OC90-associated genes across cancer lineages are OR51V1, OR10A7, and OR5K4. Each is linked with OC90 in more than 1 cancer types. Because this analysis shows association rather than direction, both OC90-to-partner and partner-to-OC90 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51V1 grouped by OC90-low versus OC90-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OC90→partner) and Y-score (partner→OC90) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	OR51V1 →	+0.074	+4.624	<.001	.006	3	1
SCLC	OR10A7 →	+0.076	+4.624	<.001	.006	3	1
SCLC	OR5K4 →	+0.077	+5.228	<.001	.002	3	1
SCLC	OR1S1 →	+0.073	+4.624	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

OR51V1 by OC90 expression — SCLC

Explore this box plot interactively →