OBSL1

Across TCGA pan-cancer cohorts, OBSL1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated OBSL1 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher OBSL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OBSL1 expression acts as an unfavorable survival marker.

CCRCC, LSCC, and LUAD are the cancer types where OBSL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.421	0.817	<.001	78	view →
LSCC	DFS	Tertile	II,III,IV	0.535	0.858	.010	11	view →
LUAD	DFS	Quartile	All	0.854	0.987	.018	9	view →
UCEC	OS	Quartile	All	0.884	1.000	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

OBSL1–CCRCC (DFS)

Open the CCRCC breakdown →