OBSL1

Across TCGA pan-cancer cohorts, OBSL1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of OBSL1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where OBSL1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types OBSL1 is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

PDAC, CCRCC, and LSCC are the cancer types where OBSL1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OBSL1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−0.378	<.001	6	view →
CCRCC	Male	All	−0.203	<.001	6	view →
LSCC	Male	III,IV	−0.176	.021	3	view →
LUAD	All	All	−0.127	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

OBSL1–PDAC

Open the PDAC breakdown →