OBSL1

Across TCGA patient cohorts, OBSL1 mutation is significantly associated with the RNA expression of many other genes, with 5,615 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OBSL1-associated genes across cancer lineages are TAF13, COPS3, and HPF1. Each is linked with OBSL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both OBSL1-to-partner and partner-to-OBSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF13 grouped by OBSL1-low versus OBSL1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OBSL1→partner) and Y-score (partner→OBSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TAF13 →	+0.570	+3.771	.001	<.001	3	5
COAD	COPS3 →	+0.555	+3.710	<.001	<.001	3	5
COAD	HPF1 →	+0.512	+3.026	.001	<.001	3	5
UCEC	MCM10 →	+0.592	+2.091	<.001	<.001	3	5
UCEC	GNPNAT1 →	+0.543	+1.669	<.001	<.001	3	5
UCEC	MRPL19 →	+0.433	+2.080	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,615 associations by consensus.

TAF13 by OBSL1 expression — COAD

Explore this box plot interactively →