OBSL1

Across TCGA patient cohorts, OBSL1 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OBSL1-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and eEF2. Each is linked with OBSL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both OBSL1-to-partner and partner-to-OBSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by OBSL1-low versus OBSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OBSL1→partner) and Y-score (partner→OBSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.653	+1.958	<.001	<.001	3	5
UCEC	Cyclin-B1 →	+0.601	+2.736	<.001	<.001	3	4
UCEC	eEF2 →	+0.380	+3.087	<.001	<.001	3	3
UCEC	PKC-a_pS657 →	-0.265	-1.838	.013	.007	3	3
UCEC	C-Raf →	+0.091	+2.000	.023	.029	3	3
UCEC	GAPDH →	+0.607	+2.392	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Caspase-7-cleavedD198 by OBSL1 expression — UCEC

Explore this box plot interactively →