OBSL1

Across TCGA cell cohorts, OBSL1 mutation is significantly associated with the mutation status of many other genes, with 5,392 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OBSL1-associated genes across cancer lineages are URB2, HELZ2, and FOXN3. Each is linked with OBSL1 in more than 6 cancer types. Because this analysis shows association rather than direction, both OBSL1-to-partner and partner-to-OBSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, URB2 grouped by OBSL1-low versus OBSL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OBSL1→partner) and Y-score (partner→OBSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	URB2 →	+2.857	+2.471	<.001	<.001	1	7
OESOPHAGUS	HELZ2 →	+2.830	+3.146	.006	.006	1	6
BLOOD_Leukemia	FOXN3 →	+3.169	+2.662	.001	.001	1	6
OVARY	SPTB →	+3.930	+3.632	.003	.003	1	6
OVARY	ANKHD1 →	+2.760	+3.510	.003	.003	1	6
PANCREAS	NEXMIF →	+5.115	+5.115	.005	.005	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,392 associations by consensus.

URB2 by OBSL1 expression — LARGE_INTESTINE

Explore this box plot interactively →