OBSCN

Across TCGA patient cohorts, OBSCN mutation is significantly associated with the total protein of many other genes, with 138 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OBSCN-associated genes across cancer lineages are Caspase-7-cleavedD198, RAD51, and ACVRL1. Each is linked with OBSCN in more than 7 cancer types. Because this analysis shows association rather than direction, both OBSCN-to-partner and partner-to-OBSCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by OBSCN-low versus OBSCN-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OBSCN→partner) and Y-score (partner→OBSCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Caspase-7-cleavedD198 →	+0.796	+1.469	<.001	<.001	3	7
KIRP	RAD51 →	+0.358	+3.000	.036	.033	3	6
STAD	ACVRL1 →	-0.162	-1.999	.001	<.001	3	6
READ	Cyclin-B1 →	+0.755	+3.169	.005	.016	1	8
STAD	Cyclin-E2 →	+0.131	+1.606	<.001	.001	3	6
SKCM	IRS1 →	+0.079	+0.769	.011	.029	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 138 associations by consensus.

Caspase-7-cleavedD198 by OBSCN expression — STAD

Explore this box plot interactively →