OBI1

Across TCGA patient cohorts, OBI1 mutation is significantly associated with the RNA expression of many other genes, with 3,509 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OBI1-associated genes across cancer lineages are MIR3927, MDH1, and SLC25A33. Each is linked with OBI1 in more than 2 cancer types. Because this analysis shows association rather than direction, both OBI1-to-partner and partner-to-OBI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3927 grouped by OBI1-low versus OBI1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OBI1→partner) and Y-score (partner→OBI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR3927 →	+0.232	+5.011	<.001	.002	3	3
UCEC	MDH1 →	+0.371	+2.787	.002	<.001	3	3
UCEC	SLC25A33 →	+0.506	+1.797	<.001	.007	3	3
UCEC	ENO1 →	+0.450	+2.518	.004	.001	3	3
LIHC	CA15P2 →	+0.177	+5.758	<.001	.003	3	2
UCEC	MEX3D →	+0.599	+3.191	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,509 associations by consensus.

MIR3927 by OBI1 expression — LUAD

Explore this box plot interactively →