OBI1

Across TCGA patient cohorts, OBI1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OBI1-associated genes across cancer lineages are ATM, HSP70, and EGFR_pY1068. Each is linked with OBI1 in more than 3 cancer types. Because this analysis shows association rather than direction, both OBI1-to-partner and partner-to-OBI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by OBI1-low versus OBI1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OBI1→partner) and Y-score (partner→OBI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.590	-2.070	<.001	.001	3	4
COAD	HSP70 →	+0.934	+2.820	.002	.035	3	2
UCEC	EGFR_pY1068 →	-0.209	-1.906	.016	.015	3	2
UCEC	Notch1 →	+0.166	+1.598	<.001	.019	3	2
UCEC	VHL →	-0.873	-1.584	<.001	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.643	+3.019	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by OBI1 expression — UCEC

Explore this box plot interactively →