OASL

Across TCGA pan-cancer cohorts, OASL mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated OASL data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher OASL mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated OASL expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where OASL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.856	0.566	.008	40	view →
PDAC	OS	Tertile	IV	0.443	0.973	.024	6	view →
CCRCC	DFS	Median	III,IV	1.000	0.808	.023	2	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.515	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

OASL–HNSC (OS)

Open the HNSC breakdown →