OAS2

Across TCGA pan-cancer cohorts, OAS2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated OAS2 data layer compared with 28 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher OAS2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OAS2 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, HNSC, and CCRCC are the cancer types where OAS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.909	1.000	.010	60	view →
HNSC	DFS	Quartile	III,IV	1.000	0.177	.024	30	view →
CCRCC	OS	Median	IV	0.123	0.785	.009	21	view →
LUAD	DFS	Median	All	0.665	0.809	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

OAS2–COAD (DFS)

Open the COAD breakdown →