OAS2

Across TCGA cell cohorts, OAS2 mutation is significantly associated with the RNA expression of many other genes, with 237 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OAS2-associated genes across cancer lineages are SPATA31E1, STH, and C18orf63. Each is linked with OAS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OAS2-to-partner and partner-to-OAS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31E1 grouped by OAS2-low versus OAS2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OAS2→partner) and Y-score (partner→OAS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SPATA31E1 →	+0.166	+4.906	<.001	.006	3	1
OESOPHAGUS	STH →	+0.076	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1
LARGE_INTESTINE	GSR →	+0.825	+3.212	.005	.006	3	1
LARGE_INTESTINE	C1QBP →	+0.957	+3.299	<.001	.004	3	1
LARGE_INTESTINE	GPR63 →	+1.069	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 237 associations by consensus.

SPATA31E1 by OAS2 expression — OESOPHAGUS

Explore this box plot interactively →