OAS1

Across TCGA pan-cancer cohorts, OAS1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated OAS1 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher OAS1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated OAS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where OAS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.772	0.958	.011	18	view →
HNSC	OS	Median	All	1.000	0.484	.038	14	view →
PDAC	OS	Median	III,IV	0.605	0.874	.021	10	view →
LSCC	DFS	Tertile	All	1.000	0.347	.001	6	view →
LUAD	DFS	Tertile	All	0.361	0.837	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

OAS1–CCRCC (DFS)

Open the CCRCC breakdown →