Across TCGA patient cohorts, OAF mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OAF-associated genes across cancer lineages are GAPDH, mTOR_pS2448, and 14-3-3_beta. Each is linked with OAF in more than 1 cancer types. Because this analysis shows association rather than direction, both OAF-to-partner and partner-to-OAF results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OAF→partner) and Y-score (partner→OAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.643	+3.169	.013	.019	3	2
UCEC	mTOR_pS2448 →	-0.194	-3.150	.007	.019	3	2
UCEC	14-3-3_beta →	-0.118	-2.973	.014	.035	3	1
UCEC	eEF2 →	+0.505	+3.000	.003	.036	3	1
UCEC	eIF4G →	+0.408	+2.459	.006	.020	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.575	-3.000	.008	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

OAF survival (RNA) · tumor vs normal (RNA) · all OAF data types